Native Proteins and Derivatives
Sigma Aldrich Fine Chemicals Biosciences Lipoprotein Lipase from Ps50MG
Lipoprotein Lipase (LPL) is majorly secreted by myocytes and adipocytes in humans and is crucial for triglyceride homeostatis. Mutations in the catalytic domain of LPL impairs its interaction with glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1). The N-terminal catalytic domain is essential for lipolysis. The C-terminal is crucial for binding lipoproteins. Altered LPL levels may play role in the pathogenesis of atherosclerosis coronary heart disease and chronic lymphocytic leukemia.
Cayman Chemical 2 3-O- 5-ChloronthrnIloy 3.3mg
A JAK3 inhibitor (IC50 11 UM) inhibits FcεRI-mediated LTC4 and LTB4 release from and 5-LO translocation to the membrane in RBL-2H3 mast cells at 10 UM reduces airway hyperresponsiveness and BALF eosinophil infiltration in a mouse model of ovalbumin-induced allergic asthma at 12 and 40 mg/kg
Cayman Chemical SpGunosIn5O 1thIotrIp 2.7mg
An FLT3 inhibitor inhibits wild-type FLT3D835Y and FLT3-ITD (IC50s 13 8 and 3 nM respectively) suppresses the growth of MV4-11 AML cells that express FLT3-ITD (GI50 7 nM) induces cell cycle arrest at the G1 phase and apoptosis in the same cells reduces intratumor FLT3-ITD autophosphorylation in a MV4-11 mouse xenograft model at 10 mg/kg
Cayman Chemical 2 3O 6AmInohexylcarbamo 3.3mg
An internal standard for the quantification of 2-deoxyuridine by GC- or LC-MS
Cayman Chemical 2OMethylgunosIn5OtrI 2.7mg
A lignan scavenges ABTS radicals in a cell-free assay (IC50 19.4 UM) inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 84.45 UM) inhibits AB42 self-aggregation in a cell-free assay at 20 UM
Cayman Chemical 2Deoxy3O Nmethylnthr 2.7mg
An alkaline phosphatase inhibitor (Ki 1.1 mM for the bovine intestine enzyme) has been used in affinity chromatography for the purification of alkaline phosphatase has been used in electrochemical modification of glassy carbon electrodes
Cayman Chemical 3OAcetyl2deoxyadenosIn 2.7mg
A diterpene with antileishmanial and gastroprotective activities induces mortality in L. donovani amastigotes (IC50 0.75 UM) reduces lesion area in a mouse model of hydrochloric acid and ethanol-induced gastric ulcers at 10 mg/kg
Cayman Chemical 3AmIno3deoxyadenosIn5 2.1mg
An agonist of PPARa activates PPARa in HepG2 cells in a reporter assay at 1 UM but does not activate PPARB or PPARY at 10 UM prevents T0901317-induced triglyceride accumulation in HepG2 cells at 3 UM scavenges ROS and peroxynitrite in cell-free assays (IC50s 39.7 and 2.39 UM respectively) inhibitsBglucuronidase and tyrosinase (IC50s 8.9 and 0.01 UM for the bovine liver and mushroom enzymes respectively) reduces age-induced increases in liver weight and triglyceride levels in a rat model of hepatic steatosis at 5 mg/kg
Cayman Chemical 3OMethylgunosIn5OtrI 2.7mg
A lignan scavenges ABTS radicals in a cell-free assay (IC50 19.4 UM) inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 84.45 UM) inhibits AB42 self-aggregation in a cell-free assay at 20 UM
Cayman Chemical Rp2DeoxyadenosIn5O 1 2.1mg
An ETA receptor antagonist (Ki 13 nM in rat aortic vascular smooth muscle cells) inhibits ET-1-induced contractions in isolated rat aortic rings and mesenteric microvessels (pA2s 8.1 and 7.97 respectively) decreases systolic blood pressure in DOCA-salt hypertensive rats at 50 mg/kg decreases MAP and LVDP in normotensive pigs at 1 and 5 mg/kg reduces myocardial infarct size as a percentage of the area at risk in a porcine model of LAD coronary artery ligation-induced ischemia-reperfusion injury
Biocare Medical, LLC Factor XIIIa Antibody - Concentrate, 1.0 ml
This is a monoclonal antibody to the A-subunit of human coagulation Factor XIII. Studies have shown it recognizes human Factor XIII Achain in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a betaglobulin found in plasma and is composed of two subunits. Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000. According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W. 320,000); whereas in platelets, only the alpha2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors (3,4). It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system (1-6). Factor XIIIa has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans (3).
Sigma Aldrich Fine Chemicals Biosciences fibronectin bovine plasma5MG
fibronectin is a glycoprotein with multiple domains. It comprises a N-terminal central binding domain and a heparin-binding domain. Bovine plasma fibronectin has polypeptide chains with disulfide linkage and corresponds to a molecular weight of 220 and 215 kDa.